Prof. Wendell Lim’s laboratory is interested in the logic of cell signaling systems: understanding how the networks of signaling proteins found in eukaryotic cells have evolved to allow cells to make complex behavioral decisions. They use two broad approaches to attack this problem. First they use biochemistry, cell biology, genetics, and computational biology to dissect the mechanisms of signaling proteins and networks. They are particularly interested in understanding how nature's toolkit of modular domains are recombined through evolution to generate new and diverse response behaviors. Second, they use synthetic biology: the redesign of biological systems. In particular, they are using various methods to create novel or modified signaling proteins and pathways, both to systematically understand network structure/function relationships and to develop engineered research tools and novel biotechnological and therapeutic applications.
For details of his research and recent publication, please visit HERE